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Related Experiment Videos

Entonox analgesia for prostatic biopsy.

I G McIntyre1, A Dixon, M L Pantelides

  • 1Department of Urology, Royal Bolton Hospital NHS Trust, Farnworth, Bolton, Lancashire, UK. iain@uroman.fsnet.co.uk

Prostate Cancer and Prostatic Diseases
|September 13, 2003
PubMed
Summary

Entonox (nitrous oxide) significantly reduces pain during prostate biopsies. Patients receiving Entonox reported minimal pain compared to those breathing air, demonstrating its analgesic efficacy.

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Area of Science:

  • Urology
  • Anesthesiology
  • Pain Management

Background:

  • Trans-rectal ultrasound (TRUS) guided prostate biopsy is a common procedure.
  • Pain is frequently reported during prostate biopsies, potentially impacting patient tolerance and compliance.
  • Effective analgesia is crucial for improving patient experience during TRUS-guided prostate biopsy.

Purpose of the Study:

  • To evaluate the efficacy of Entonox (nitrous oxide) as a patient-administered analgesic during TRUS-guided prostate biopsy.
  • To compare pain levels experienced by patients receiving Entonox versus those receiving air.
  • To assess the impact of Entonox on patient-reported pain during prostate biopsy.

Main Methods:

  • Prospective, randomized, double-blind study design.
  • 50 patients undergoing sextant prostatic biopsies by a single surgeon.
  • Patients inhaled either Entonox or air during the procedure.
  • Pain was quantified using a 100 mm visual analogue pain scale.

Main Results:

  • Patients breathing air reported moderate pain (median score 34).
  • Patients breathing Entonox reported minimal pain (median score 11).
  • Two Entonox users and one air user experienced severe pain, with no significant adverse events reported.

Conclusions:

  • Prostate biopsy without analgesia results in moderate pain.
  • Entonox provides significant pain reduction during TRUS-guided prostate biopsy.
  • Entonox is an effective and well-tolerated analgesic option for this procedure.

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