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Morphological features correlation with serum tumour markers in prostatic carcinoma
Saeed Afzal1, Mumtaz Ahmad, Sajid Mushtaq
1Department of Pathology, Army Medical College, Rawalpindi.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|September 16, 2003
Summary
This study correlates Gleason grades and scores in prostate cancer with tumor markers. Prostate-specific antigen (PSA) demonstrated superior sensitivity and specificity compared to prostatic acid phosphatase (PAP).
Area of Science:
- Oncology
- Pathology
- Urology
Background:
- Prostatic carcinoma diagnosis and staging are critical for patient management.
- Gleason grading and scoring are established morphological parameters.
- Tumor markers like PSA and PAP are used in prostate cancer assessment.
Purpose of the Study:
- To determine Gleason grades and scores in prostatic carcinoma.
- To investigate the correlation between Gleason features and serum tumor markers (PSA and PAP).
Main Methods:
- A descriptive study involving 50 cases of prostatic carcinoma.
- Gleason grading and scoring performed using Hematoxylin and Eosin (HE) staining.
- Pre-operative serum Prostatic Acid Phosphatase (PAP) and Prostate-Specific Antigen (PSA) assays conducted.
Main Results:
- The majority of patients (56%) had Gleason scores of 5-7.
- Serum PSA levels between 10.0-50.0 ng/ml were observed in 58% of cases, with 26% showing >50 ng/ml (84% sensitivity).
- Serum PAP levels >3.7 U/l were found in 70% of patients (70% sensitivity).
Conclusions:
- The Gleason grading system is a reliable morphological predictor in prostate cancer.
- Serum PSA exhibited higher sensitivity and specificity in correlation with Gleason grades and scores than serum PAP.
- Serum PAP showed a better correlation with morphological features compared to serum PSA.