Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis

Area of Science:

• Neuro-oncology
• Molecular Pathology
• Genetics

Background:

• Diffuse hemispheric glioma, H3 G34-mutant, is a rare, high-grade infiltrative brain tumor.
• Typically affects adolescents and young adults, with H3-3A gene mutations at the G34 position being oncogenic.
• Characterized by diverse histology, a distinct immunophenotype, and poor prognosis.

Purpose of the Study:

• To describe the clinicopathological features of H3 G34-mutant diffuse hemispheric glioma in the Pakistani population.
• To report on the histopathological and immunohistochemical findings in a cohort of Pakistani patients.
• To address the lack of published data on this specific glioma subtype in Pakistan.

Main Methods:

• Retrospective analysis of 13 cases of diffuse hemispheric glioma, H3 G34-mutant.
• Detailed histopathological examination of tumor morphology.
• Comprehensive immunohistochemical workup for each case.

Main Results:

• The study identified 13 cases of H3 G34-mutant diffuse hemispheric glioma in Pakistani patients.
• Significant morphological variability was observed across the cases.
• Complete immunohistochemical profiles were established for all analyzed tumors.

Conclusions:

• H3 G34-mutant diffuse hemispheric glioma presents with diverse histological features in the Pakistani population.
• This study provides crucial insights into the characteristics of this rare tumor in a previously underrepresented demographic.
• Further research is warranted to understand the full spectrum and implications of this glioma subtype.