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Regulation of gene expression in oncogenically transformed cells
1Département de biochimie, Université de Montréal, Québec, Canada.
Abstract:
Several genes expressed in response to growth factors are also regulated aberrantly in oncogenically transformed cells. The constitutive expression of genes encoding extracellular proteases, transcription factors, and cytokines is often correlated with cell transformation. In several instances, the uncontrolled expression of these genes is the result of transcriptional activation. Therefore, much attention has been devoted to the study of promoter function in transformed cells. We now review the results of recent investigations on transformation-dependent gene expression. The activation of several transcription factors in oncogenically-transformed cells is described. Results regarding the regulation of promoters through PRD II/kappa B are presented for cells transformed by a variety of oncogenes. Finally, we discuss the significance of transcription factor activation in the process of cell transformation.
Insights
Aberrant gene expression in cancer cells often stems from transcriptional activation. This review highlights how transcription factors and promoter regulation, particularly PRD II/kappa B, drive oncogenic cell transformation.
Area of Science:
- Molecular Biology
- Cancer Research
- Genetics
Background:
- Genes responding to growth factors are often abnormally regulated in cancer.
- Constitutive expression of proteases, transcription factors, and cytokines correlates with cell transformation.
- Uncontrolled gene expression in cancer is frequently due to transcriptional activation.
Purpose of the Study:
- To review recent findings on transformation-dependent gene expression.
- To describe transcription factor activation in oncogenically transformed cells.
- To discuss the role of transcription factor activation in cell transformation.
Main Methods:
- Review of recent investigations on gene expression in transformed cells.
- Analysis of transcription factor activation mechanisms.
- Examination of promoter regulation, specifically PRD II/kappa B, in oncogene-transformed cells.
Main Results:
- Several transcription factors are activated in oncogenically transformed cells.
- PRD II/kappa B promoter elements are regulated in cells transformed by various oncogenes.
- Evidence supports the link between transcription factor activation and cell transformation.
Conclusions:
- Transcription factor activation is a key mechanism in oncogenic cell transformation.
- Understanding promoter regulation, such as PRD II/kappa B, is crucial for cancer research.
- Aberrant gene expression driven by transcription factors contributes significantly to cancer development.