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Bilayered phospholipid micelles and capillary electrophoresis: a new additive for electrokinetic chromatography
Lisa A Holland1, Alyison M Leigh
1Department of Chemistry, West Virginia University, Morgantown, WV 26506, USA. lisa.holland@mail.wvu.edu
Electrophoresis
|September 16, 2003
Abstract:
Phospholipid micelles and bilayered micelles (bicelles) were investigated as a new media for electrokinetic chromatography. The benefit to using these additives for micellar electrokinetic chromatography (MEKC) is the potential of a simple bilayer membrane model operated with fast analysis time, and low sample injection volumes. The system is used to separate peptides/protein and is tested with a series of beta-blockers. The results suggest that bicelle electrokinetic chromatography provides selectivity and holds potential as an alternative approach to modeling membrane phenomenon.