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HLA-B27 polymorphism in the Malays
J S Dhaliwal1, C L Too, M Lisut
1Allergy and Immunology Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia. jasbir@imr.gov.my
Tissue Antigens
|September 17, 2003
Summary
The Human Leukocyte Antigen B27 (HLA-B27) allele occurs in 3.99% of Malay individuals. Subtypes HLA-B*2706 and HLA-B*2704 are most common in this population.
Area of Science:
- Immunogenetics
- Population Genetics
- Molecular Anthropology
Background:
- The Human Leukocyte Antigen B27 (HLA-B27) is a crucial gene in the immune system.
- Its prevalence varies significantly across different ethnic populations.
- Understanding HLA-B27 distribution is vital for genetic and anthropological studies.
Purpose of the Study:
- To determine the frequency and distribution of HLA-B27 and its subtypes within the Malay population.
- To provide baseline data for future research on HLA-B27 related conditions in this demographic.
Main Methods:
- HLA typing was performed on 878 Malay subjects.
- High-resolution typing for HLA-A, HLA-B, and HLA-DR loci was conducted.
- Allele and subtype frequencies were calculated based on positive HLA-B27 findings.
Main Results:
- HLA-B27 was detected in 3.99% of the studied Malay subjects.
- The predominant subtypes identified were HLA-B*2706 (72.2%) and HLA-B*2704 (19.4%).
- Less frequent subtypes included HLA-B*2705 (5.6%) and HLA-B*2707 (2.8%).
Conclusions:
- HLA-B27 is present in the Malay population with a notable frequency of 3.99%.
- The genetic profile of HLA-B27 in Malays is characterized by a high prevalence of the HLA-B*2706 subtype.
- These findings contribute to the understanding of HLA polymorphism in Southeast Asian populations.