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[Paraproteinemia and motor neuron disease]
Rinsho Shinkeigaku = Clinical Neurology
|October 1, 1992
Summary
Motor neuron disease (MND) is linked to paraproteins in 11.3% of patients, suggesting a connection between MND and monoclonal gammopathy. This study found IgG, IgM, and IgA monoclonal components in MND patients, supporting a probable association.
Area of Science:
- Neurology
- Immunology
- Hematology
Context:
- Motor neuron disease (MND) is a group of neurological disorders characterized by progressive loss of motor neurons.
- The presence of paraproteins in some MND patients suggests a potential link to monoclonal gammopathy.
Purpose:
- To investigate the association between motor neuron disease and monoclonal gammopathy.
- To determine the incidence and type of monoclonal immunoglobulins in MND patients.
Summary:
- Serum immunofixation was used to analyze monoclonal immunoglobulins in 53 MND patients.
- A 11.3% incidence of paraproteins was observed, exceeding general population rates.
- Monoclonal components included IgG, IgM, and IgA, with four patients diagnosed with amyotrophic lateral sclerosis and two with spinal progressive muscular atrophy.
Impact:
- These findings support the concept of a probable association between MND and benign monoclonal gammopathy.
- The study highlights the importance of screening for monoclonal gammopathy in MND patients.
- Further research may elucidate the underlying mechanisms connecting these conditions.