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Bacteriuria in patients with glomerular diseases.

S O McLigeyo1, L S Otieno, C Kanja

  • 1Department of Medicine, College of Health Sciences, University of Nairobi, Kenya.

East African Medical Journal
|November 1, 1992
PubMed
Summary

Significant bacteriuria (bacteria in urine) is 9x more common in African patients with glomerular disease. Proteinuria may promote bacterial growth, necessitating screening for these patients.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Urology

Background:

  • Bacteriuria, the presence of bacteria in urine, is a common concern.
  • Glomerular diseases can affect kidney function and may influence infection risk.
  • Understanding bacteriuria prevalence in specific populations is crucial for public health.

Purpose of the Study:

  • To compare the prevalence of significant bacteriuria in healthy African subjects versus patients with glomerular disease.
  • To identify common bacterial uropathogens in both groups.
  • To investigate the correlation between proteinuria and bacteriuria in patients with kidney disease.

Main Methods:

  • A comparative study involving 697 healthy African subjects and 116 patients with glomerular disease.
  • Urine culture analysis to detect significant bacteriuria.
  • Identification of bacterial species from positive cultures.
  • Correlation analysis between proteinuria levels and bacteriuria prevalence.

Main Results:

  • 1.7% of healthy subjects had significant bacteriuria, with E. coli being the most common pathogen.
  • 15.5% of patients with glomerular disease had significant bacteriuria, a nine-fold increase compared to healthy controls.
  • Commonly isolated organisms in glomerular disease patients included E. coli, Staphylococcus aureus, and Proteus species.
  • Bacteriuria prevalence in females with glomerular disease correlated with 24-hour protein loss.

Conclusions:

  • Patients with glomerular disease exhibit a significantly higher prevalence of bacteriuria.
  • Proteinuria may create a favorable environment for bacterial growth in the urinary tract.
  • Routine screening and appropriate treatment for bacteriuria are recommended for all patients with glomerular disease.

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