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[Markers for smoking].

J Pré1

  • 1Laboratoire de Biochimie Clinique, UFR de Médecine de l'Université Paris-Nord, Bobigny, France.

Pathologie-Biologie
|December 1, 1992
PubMed
Summary

Measuring exposure to cigarette smoke is crucial for preventive medicine. The thiocyanate/creatinine ratio in urine offers a reliable, noninvasive method for assessing recent exposure to tobacco smoke.

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Area of Science:

  • Biochemistry
  • Toxicology
  • Preventive Medicine

Context:

  • Quantifying exposure to cigarette smoke is essential due to its known adverse health effects.
  • Various chemical markers exist, including nicotine, cotinine, carbon monoxide, carboxyhemoglobin, and thiocyanate.
  • These markers differ in ease of use, cost, specificity, and sensitivity.

Purpose:

  • To review methods for the quantitative and objective measurement of cigarette smoke exposure.
  • To highlight the utility of specific chemical markers for assessing tobacco smoke exposure.

Summary:

  • Chemical markers like nicotine, cotinine, carbon monoxide, carboxyhemoglobin, and thiocyanate can measure cigarette smoke exposure.
  • The thiocyanate/creatinine ratio in urine is presented as a reliable, noninvasive, and cost-effective marker for evaluating exposure.
  • Currently, no marker exists for cumulative exposure, but plasma fluorescent lipoperoxides may indicate in vivo toxicity.

Impact:

  • Provides a comprehensive overview of chemical markers for cigarette smoke exposure assessment.
  • Identifies the thiocyanate/creatinine ratio as a practical tool for preventive medicine.
  • Highlights the need for markers of cumulative exposure and potential indicators of toxicity.

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