Related Experiment Videos
Left ventricular hypertrophy, myocardial blood flow and coronary flow reserve
1Department of Medicine, Clinic and Polyclinic B, University of Düsseldorf, FRG.
Insights
Coronary reserve is reduced in cardiac hypertrophy but normal in hypertrophic obstructive cardiomyopathy and aortic stenosis. Long-term vasodilator therapy can improve coronary reserve in hypertensive heart disease.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Hypertrophic heart disease encompasses various conditions characterized by left ventricular hypertrophy.
- Understanding coronary hemodynamics is crucial for managing these conditions.
Purpose of the Study:
- To review and synthesize data on coronary hemodynamics in hypertrophic heart disease over the past 15 years.
- To analyze alterations in coronary reserve across different forms of cardiac hypertrophy.
Main Methods:
- Literature review of studies published within the last 15 years.
- Analysis of data concerning coronary reserve and left ventricular hypertrophy.
Main Results:
- Coronary reserve is reduced in concentric cardiac hypertrophy.
- Coronary reserve remains normal in hypertrophic obstructive cardiomyopathy and aortic stenosis despite significant left ventricular hypertrophy.
- A moderate decrease in coronary reserve is observed in aortic incompetence and dilated essential hypertension.
Conclusions:
- Coronary hemodynamics vary significantly depending on the type of hypertrophic heart disease.
- Long-term vasodilator therapy shows potential for improving coronary reserve in hypertensive heart disease.
Abstract:
In this review, the coronary haemodynamics of hypertrophic heart disease are discussed with reference to data published over the last 15 years. Coronary reserve is reduced in the presence of concentric cardiac hypertrophy, but is similar to normal in hypertrophic obstructive cardiomyopathy and aortic stenosis, despite marked left ventricular hypertrophy. A moderate decrease in coronary reserve is found in aortic incompetence and in dilated essential hypertension. In hypertensive heart disease, improvement in coronary reserve can be achieved by long-term vasodilator therapy.