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Related Experiment Videos

Heart in pituitary diseases.

J Hradec1, J Marek, J Král

  • 1IIIrd Department of Internal Medicine, Charles University, 1st School of Medicine, Prague, Czechoslovakia.

Cor Et Vasa
|January 1, 1992
PubMed
Summary

Growth hormone (GH) overproduction causes acromegaly, leading to heart problems like hypertension and cardiac hypertrophy. Early treatment of acromegaly can reverse these cardiovascular effects.

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Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Disorders

Background:

  • Growth hormone (GH) is the only pituitary hormone directly impacting cardiac function and metabolism.
  • Chronic GH overproduction in adults results in acromegaly, characterized by hypertension and cardiac hypertrophy.
  • The "acromegalic heart" is a distinct clinical entity requiring thorough investigation.

Purpose of the Study:

  • To investigate the cardiovascular manifestations in a cohort of acromegaly patients.
  • To elucidate the direct role of GH in the development of cardiac hypertrophy and hypertension.
  • To assess the reversibility of cardiac and hypertensive changes after GH normalization.

Main Methods:

  • Clinical research on a unique group of 78 acromegaly patients.
  • Long-term follow-up of patients with acromegaly.
  • Analysis of clinical findings and existing experimental data in the literature.

Main Results:

  • Cardiac hypertrophy in acromegaly is directly caused by GH's effect on the myocardium.
  • Hypertension, present in 50% of patients, is volume-related and adds to left ventricular hypertrophy.
  • Cardiac hypertrophy and hypertension show partial reversibility upon elimination of GH overproduction.

Conclusions:

  • Early and aggressive treatment of acromegaly is crucial for managing cardiovascular complications.
  • GH directly contributes to cardiac hypertrophy in acromegaly.
  • Intervention can lead to significant, though not always complete, reversal of cardiac and hypertensive abnormalities.

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