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[Congenital syphilis].

C Kurzke1, W Handrick, R Schille

  • 1Universitäts-Kinderklinik, Leipzig, Deutschland.

Padiatrie Und Grenzgebiete
|January 1, 1992
PubMed
Summary
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Congenital syphilis (Lues connata) can occur even with negative maternal tests during pregnancy. Early diagnosis and penicillin treatment are crucial for infant recovery.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Context:

  • Congenital syphilis (Lues connata) presents diagnostic challenges in newborns.
  • Maternal syphilis screening tests during pregnancy may yield false negatives.

Purpose:

  • To report on four cases of congenital syphilis in infants.
  • To highlight diagnostic difficulties and treatment outcomes.

Summary:

  • Four infants diagnosed with congenital syphilis are presented, with three in early stages.
  • Clinical findings included anemia, abnormal blood counts, hepatosplenomegaly, and bone abnormalities.
  • Despite negative maternal prenatal syphilis tests, placental transfer of pathogens was suspected. Treatment with penicillin was effective, with no Jarisch-Herxheimer reactions observed.

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Impact:

  • Negative maternal syphilis tests do not rule out congenital syphilis in newborns.
  • Congenital syphilis should be considered in newborns with undiagnosed infectious conditions.
  • Routine serodiagnostic syphilis testing for all newborns before discharge is recommended.