[An analysis of the causes of glaucomatous visual function damage by computed multifactorial stepwise regression]

Area of Science:

• Ophthalmology
• Hematology
• Medical Research

Background:

• Glaucoma, particularly primary open-angle glaucoma (POAG), is a leading cause of irreversible blindness.
• Understanding the multifactorial nature of visual field deterioration in POAG is crucial for effective management.
• Previous research suggests various factors contribute to glaucoma progression, but specific mechanisms require further elucidation.

Purpose of the Study:

• To identify key factors associated with quantitative visual field deterioration in POAG patients.
• To investigate the role of hemorheological indices and antioxidant capabilities in POAG progression.
• To explore the potential link between POAG, blood hyperviscosity syndrome, and ocular hemodynamics.

Main Methods:

• Multifactorial stepwise regression analysis was employed to assess 28 potential factors.
• Quantitative visual field data was analyzed in relation to various clinical and physiological parameters.
• Hemorheological indices and red cell membrane protein antioxidant capability were specifically evaluated.

Main Results:

• Hemorheological indices were the most significant predictors of visual field deterioration in POAG.
• Patients with severe visual damage showed a particular correlation with these hemorheological factors.
• Reduced antioxidant capability in red cell membrane protein was observed in POAG patients.

Conclusions:

• POAG may be associated with blood hyperviscosity syndrome.
• Elevated intraocular pressure and decreased ocular arterial pressure exacerbate visual function damage in POAG.
• Hemorheological status is a critical determinant of visual field progression in POAG.