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Indomethacin treatment in children with daytime frequency of micturition
1Department of Paediatrics, Shanghai Pudong Central Hospital, Peoples Republic of China.
Insights
Indomethacin effectively treats daytime urinary frequency (DUFC) in children. This low-dose treatment significantly reduced urination frequency by inhibiting prostaglandin synthesis, improving tubular function and increasing urine pH.
Area of Science:
- Pediatric Nephrology
- Pharmacology
Background:
- Daytime urinary frequency (DUFC) is a common condition in children.
- Current treatment options for DUFC may have limitations.
Purpose of the Study:
- To evaluate the efficacy of indomethacin in treating pediatric DUFC.
- To investigate the potential mechanism of action for indomethacin in DUFC.
Main Methods:
- A randomized controlled trial involving 30 children with DUFC.
- Group 1 received oral indomethacin (1 mg/kg thrice daily for 7 days).
- Group 2 initially received chloramphenicol, then indomethacin.
Main Results:
- Indomethacin significantly reduced urinary frequency from 26.3 to 11.7 instances.
- Chloramphenicol showed no effect on urinary frequency.
- Indomethacin increased plasma carbon dioxide-combining power, urine osmolality, and urine pH.
- Indomethacin decreased urine sodium and potassium levels.
Conclusions:
- Low-dose indomethacin is an effective short-term treatment for pediatric DUFC.
- Indomethacin likely acts by inhibiting prostaglandin synthesis, altering renal tubular function.
- Further research into prostaglandin inhibition for DUFC is warranted.
Abstract:
Thirty children with daytime urinary frequency (DUFC) were randomly divided into two groups. The first group was given oral indomethacin, 1 mg/kg per dose, three times a day for 7 days. The frequency of urination fell from 26.3 +/- 2.3 to 11.7 +/- 2.8 at the end of the treatment period. The second group was treated with oral chloramphenicol, 30 mg/kg per day, in four divided doses for 7 days. Their urinary frequency did not change. They were then treated with a 1-week course of indomethacin and responded in a similar manner to group 1 patients. The use of indomethacin was accompanied by significant increases in plasma carbon dioxide-combining power, urine osmolality and urine pH; urine sodium and potassium levels decreased. These results show that a short course of indomethacin, in low dose, improves DUFC. We propose that it acts by inhibiting prostaglandin synthesis which modifies tubular function and increases urinary pH.