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[Transdermal nitroglycerin in patients with stable angina]
J A Ramires1, N Ghorayeb, A P Mansur
1INCOR, São Paulo.
Arquivos Brasileiros De Cardiologia
|February 1, 1992
Summary
Nitroglycerin patches effectively reduced angina symptoms and nitrate use in patients with stable angina pectoris. Patient compliance with transdermal nitroglycerin was excellent over 12 weeks.
Area of Science:
- Cardiology
- Pharmacology
- Clinical Medicine
Context:
- Stable angina pectoris is a common cardiovascular condition.
- Effective management of angina symptoms is crucial for patient quality of life.
- Transdermal drug delivery offers a convenient administration route.
Purpose:
- To assess the efficacy and tolerability of nitroglycerin patches in patients with stable angina pectoris.
- To evaluate the impact of nitroglycerin patches on angina frequency and medication use.
- To determine patient compliance with transdermal nitroglycerin therapy.
Summary:
- A 12-week prospective study involved 1539 patients with stable angina pectoris.
- Patients received 5 mg or 10 mg nitroglycerin patches, with clinical evaluations and exercise tests performed regularly.
- Significant reductions were observed in angina episodes, sublingual nitrate consumption, blood pressure, and positive treadmill tests.
Impact:
- Nitroglycerin patches demonstrate significant efficacy in managing stable angina pectoris.
- The transdermal administration of nitroglycerin was well-tolerated and showed excellent patient compliance.
- This study supports the use of nitroglycerin patches as an effective treatment option for stable angina.