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Wheat-dependent exercise-induced anaphylaxis: inhibition by sodium bicarbonate
T Katsunuma1, Y Iikura, A Akasawa
1Department of Allergy, National Children's Hospital, Tokyo, Japan.
Annals of Allergy
|February 1, 1992
Summary
Sodium bicarbonate may prevent recurrent anaphylaxis triggered by wheat and exercise. This treatment also inhibited decreases in blood pH and elevations in plasma histamine levels during allergic reactions.
Area of Science:
- Allergy and Immunology
- Exercise Physiology
- Gastroenterology
Background:
- Wheat-dependent exercise-induced anaphylaxis (WDIHA) is a rare condition.
- Anaphylaxis symptoms can recur after initial treatment.
- The role of blood pH in WDIHA is not fully understood.
Observation:
- A case of WDIHA is presented.
- Symptoms reappeared after wheat and exercise provocation.
- Sodium bicarbonate pretreatment was administered.
Findings:
- Sodium bicarbonate inhibited the reappearance of anaphylactic symptoms.
- Blood pH decrease and plasma histamine elevation were also inhibited.
- This suggests a link between blood pH and histamine release in WDIHA.
Implications:
- Sodium bicarbonate may be a potential preventive strategy for WDIHA.
- Further research is needed to confirm efficacy and optimal dosage.
- Understanding the physiological mechanisms of WDIHA can lead to better treatments.