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Thrombomodulin, an endothelial anticoagulant; its structure, function and expression
1IIIrd Department of Internal Medicine, Kogashima University, School of Medicine, Japan.
Japanese Circulation Journal
|February 1, 1992
Abstract:
Thrombomodulin is an endothelium-associated glycoprotein that converts thrombin from a procoagulant protease to an anticoagulant. Thrombin, a key enzyme in thrombus formation, binds to thrombomodulin on the endothelium. However after thrombin binds to thrombomodulin, it fails to act on the coagulation factors and platelets, and its ability to activate protein C is enhanced more than 1,000-fold. This article reviews the recent progress in the study of thrombomodulin.