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Molecular cloning and characterization of a novel rat activin receptor
R Legerski1, X Zhou, J Dresback
1Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Biochemical and Biophysical Research Communications
|March 16, 1992
Abstract:
We report the isolation of a full-length rat cDNA for a new activin receptor. The deduced amino acid sequence of this receptor shows 67 percent overall identity with that of a previously identified mouse activin receptor. As predicted for the mouse activin receptor, the amino acid sequence of the rat receptor is consistent with a polypeptide containing an extracellular ligand binding domain, a hydrophobic transmembrane domain, and a serine/threonine kinase intracellular domain. In an expression assay, this new receptor was found to bind I125 radiolabeled activin.