Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Depersonalization disorder: a functional neuroanatomical perspective.

Mary L Phillips1, Mauricio Sierra

  • 1Institute of Psychiatry, Denmark Hill, London, UK. m.phillips@iop.kcl.ac.uk

Stress (Amsterdam, Netherlands)
|September 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm.

Bipolar disorders·2026
Same author

Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

White matter abnormalities in bipolar II and unipolar depression - Evidence from fixel-based analysis.

Journal of affective disorders·2026
Same author

Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals.

eLife·2026
Same author

Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.

Biological psychiatry·2026

Depersonalization involves emotional numbing due to altered autonomic and neural responses. This study suggests a reversal in how the brain processes emotional stimuli in patients with depersonalization.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Depersonalization is characterized by emotional numbing and a diminished subjective experience of affect.
  • Patients report a lack of emotional "coloring" in their perceptions, contributing to feelings of unreality.

Purpose of the Study:

  • To investigate the neural and psychophysiological underpinnings of emotional deficits in depersonalization.
  • To explore the role of prefrontal cortex activity in the appraisal of emotional stimuli in depersonalized individuals.

Main Methods:

  • Review of clinical reports, neuroimaging studies, and psychophysiological data in depersonalization.
  • Analysis of autonomic responses and neural activity patterns during emotional stimulus processing.

Main Results:

Related Experiment Videos

  • Attenuated autonomic responses observed in depersonalization.
  • Decreased activity in neural regions crucial for affective generation.
  • Increased prefrontal cortical activity linked to contextualization and appraisal of emotional information.

Conclusions:

  • Emotional numbing in depersonalization may stem from altered autonomic and neural processing of emotive stimuli.
  • Findings suggest a potential reversal of typical response patterns in the brain's emotional circuitry.