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Epithelioid cell histiocytoma. A clinicopathologic and immunohistochemical study of eight cases
A H Mehregan1, D R Mehregan, A Broecker
1Pinkus Dermatopathology Laboratory, Monroe, Michigan.
Background:
Epithelioid cell histiocytomas histologically resemble the intradermal form of Spitz nevus.
Objective:
We have studied eight patients with epithelioid cell histiocytoma.
Methods:
In addition to the routine stains, histologic sections were prepared by immunohistochemical techniques for S-100 protein, HMB-45, vimentin, alpha 1-antitrypsin, and common leukocyte antigen.
Results:
Epithelioid cell histiocytoma is characterized by proliferation of angulated epithelioid cells with abundant eosinophilic cytoplasm. Immunostaining for S-100 protein and HMB-45 were negative. The majority of cells had positive reactions to staining for vimentin and alpha 1-antitrypsin. Approximately 20% to 25% of cells also gave positive reactions to common leukocyte antigen.
Conclusion:
Immunostainings are useful in the differential diagnosis of epithelioid cell histiocytoma from the intradermal form of Spitz nevus.