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A case of skin hyperpigmentation due to alpha-MSH hypersecretion
J S Pears1, R T Jung, W Bartlett
1Department of Medicine, University of Dundee Medical School, Ninewells Hospital, U.K.
The British Journal of Dermatology
|March 1, 1992
Summary
Pituitary alpha-melanocyte-stimulating hormone (alpha-MSH) hypersecretion caused generalized skin hyperpigmentation. Glucocorticoid therapy resolved this novel acetylation profile and related symptoms.
Area of Science:
- Endocrinology
- Dermatology
- Oncology
Background:
- Generalized skin hyperpigmentation can indicate underlying endocrine disorders.
- Alpha-melanocyte-stimulating hormone (alpha-MSH) plays a role in skin pigmentation.
Observation:
- A patient presented with generalized skin hyperpigmentation, most prominent in sun-exposed areas.
- The patient exhibited secondary adrenal dysfunction, lymphadenopathy, glomerulonephritis, and malabsorption.
Findings:
- Analysis revealed a novel alpha-MSH acetylation profile in the patient compared to controls.
- This profile differed from those seen in Cushing's disease and Nelson's syndrome.
Implications:
- Glucocorticoid replacement therapy effectively suppressed alpha-MSH hypersecretion.
- This treatment led to complete resolution of the patient's complex clinical presentation.