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Related Experiment Videos

Beriberi cardiomyopathy.

W Djoenaidi1, S L Notermans, G Dunda

  • 1Department of Neurology, Airlangga University, Faculty of Medicine, Dr Soetomo Hospital, Surabaya, Indonesia.

European Journal of Clinical Nutrition
|March 1, 1992
PubMed
Summary
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Beriberi, a thiamine deficiency disease, remains endemic in Indonesia. Prompt thiamine treatment significantly improved cardiac beriberi symptoms and polyneuropathy, highlighting the importance of early diagnosis and intervention.

Area of Science:

  • Nutritional Neurology
  • Cardiology
  • Clinical Medicine

Background:

  • Beriberi remains an endemic health concern in Indonesia, with subclinical cases frequently observed.
  • Cardiovascular complications, particularly chronic non-alcoholic cardiac beriberi, pose a significant clinical challenge.
  • Shoshin beriberi represents a severe, classical manifestation of thiamine deficiency.

Observation:

  • Three patients presented with diverse beriberi manifestations: Shoshin beriberi and chronic cardiac beriberi.
  • All patients exhibited dramatic improvement in cardiac symptoms following treatment with thiamine tetrahydrofurfuryl disulfide.
  • Polyneuropathy showed some improvement, correlating with neurophysiologic findings and somatosensory evoked potentials (SSEPs).

Findings:

  • Somatosensory evoked potentials (SSEPs) offer valuable clinical insights into beriberi-related polyneuropathy.

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  • Thiamine treatment demonstrated efficacy in reversing both cardiac and neurological deficits associated with beriberi.
  • Untreated cardiovascular beriberi carries a high mortality rate.

    • Implications:

    • Routine thiamine administration should be considered for patients with unexplained heart failure.
    • Early detection and treatment of beriberi can prevent severe cardiac and neurological sequelae.
    • SSEPs can aid in the objective assessment and monitoring of beriberi polyneuropathy.