Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histoplasmosis in Indianapolis.

L J Wheat1

  • 1Indiana University School of Medicine, Richard L. Roudebush Veterans Administration Hospital, Indianapolis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of an oral probiotic nutraceutical containing Aspergillus-derived ingredients on a serum and urine galactomannan antigen assay in dogs.

Veterinary journal (London, England : 1997)·2020
Same author

Antigen Concentrations as an Indicator of Clinical Remission and Disease Relapse in Cats with Histoplasmosis.

Journal of veterinary internal medicine·2016
Same author

Treatment of Disseminated Aspergillosis with Posaconazole in 10 Dogs.

Journal of veterinary internal medicine·2015
Same author

Cryptococcal meningitis post autologous stem cell transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2014
Same author

Serum and urine Blastomyces antigen concentrations as markers of clinical remission in dogs treated for systemic blastomycosis.

Journal of veterinary internal medicine·2014
Same author

Donor-derived fungal infections in organ transplant recipients: guidelines of the American Society of Transplantation, infectious diseases community of practice.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012

Recurrent histoplasmosis outbreaks highlight its impact on AIDS patients. Diagnosis and treatment, including Amphotericin B and Itraconazole, are crucial for managing this opportunistic infection.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Recurrent histoplasmosis outbreaks in Indianapolis since 1978 have significantly advanced understanding of the disease.
  • Histoplasmosis is now the primary opportunistic infection among individuals with acquired immunodeficiency syndrome (AIDS) in Indianapolis.
  • Host factors critically influence the clinical presentation of histoplasmosis.

Purpose of the Study:

  • To review the epidemiology, clinical manifestations, diagnostic methods, and treatment strategies for histoplasmosis.
  • To emphasize the challenges and management of histoplasmosis in immunocompromised populations, particularly those with AIDS.
  • To discuss the evolving diagnostic landscape and therapeutic options for histoplasmosis.

Main Methods:

  • Review of clinical data and epidemiological trends of histoplasmosis outbreaks.

Related Experiment Videos

  • Analysis of diagnostic accuracy for cultural, serological, and antigen detection methods.
  • Evaluation of treatment outcomes with Amphotericin B, Itraconazole, and other antifungal agents.

    • Main Results:

    • Underlying lung disease can lead to chronic pulmonary histoplasmosis.
    • Immunosuppression increases the risk of disseminated histoplasmosis.
    • Inflammatory conditions like arthritis and pericarditis are common in acute histoplasmosis.
    • Radioimmunoassay for polysaccharide antigen offers a novel diagnostic approach.
    • Amphotericin B is highly effective, while Itraconazole shows promise for less severe cases.
    • Antigen detection aids in monitoring treatment response and identifying relapses.

    Conclusions:

    • Histoplasmosis requires careful diagnosis considering host factors and diagnostic test limitations.
    • Amphotericin B remains the standard treatment, with Itraconazole as a viable alternative for select patients.
    • Long-term maintenance therapy is essential for individuals with AIDS or other immunosuppressive conditions to prevent relapse.
    • Antigen detection is valuable for therapeutic monitoring and relapse detection in histoplasmosis management.