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[Therapeutic approach in peripheral neuropathies].

J M Léger1

  • 1Clinique des maladies du système nerveux, hôpital de la Salpêtrière, Paris.

La Revue Du Praticien
|January 1, 1992
PubMed
Summary

Peripheral neuropathies remain challenging to treat due to severe nerve damage and slow repair. However, recent advances show promise in treating inflammatory demyelinating polyneuropathies and ongoing trials for diabetic neuropathy offer hope.

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Area of Science:

  • Neurology
  • Immunology
  • Diabetology

Background:

  • Peripheral neuropathies often present with severe nerve lesions and slow axonal repair, leading to disappointing treatment outcomes.
  • Dysimmune-origin inflammatory demyelinating polyneuropathies pose significant clinical challenges.
  • Neuropathies associated with monoclonal gammopathies and diabetic neuropathy require effective therapeutic strategies.

Purpose of the Study:

  • To review recent advances in the treatment of peripheral neuropathies.
  • To highlight emerging therapies for inflammatory demyelinating polyneuropathies and neuropathies of specific origins.
  • To discuss ongoing therapeutic trials for challenging neuropathy types.

Main Methods:

  • Review of recent clinical studies and therapeutic trials.
  • Analysis of treatment efficacy for various peripheral neuropathy subtypes.
  • Focus on immunomodulatory therapies and novel drug targets.

Main Results:

  • Plasma exchange and intravenous human plasma immunoglobulins show significant advances in treating inflammatory demyelinating polyneuropathies.
  • Therapeutic trials are underway for neuropathies linked to monoclonal gammopathies (IgM).
  • Ongoing studies for diabetic neuropathy involve aldolase reductase inhibitors and gangliosides.

Conclusions:

  • While peripheral neuropathy treatment remains difficult, recent immunomodulatory therapies offer improved outcomes for inflammatory demyelinating polyneuropathies.
  • Active research and clinical trials are exploring new treatments for specific neuropathy types, including diabetic and gammopathy-associated neuropathies.
  • Further investigation into novel therapeutic agents and mechanisms is crucial for advancing peripheral neuropathy management.

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