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High-dose tetracycline therapy in severe acne
Archives of Dermatology
|April 1, 1976
Summary
High-dose tetracycline therapy effectively treated severe, resistant acne in most patients. While side effects occurred, treatment was rarely stopped, indicating a favorable risk-benefit profile for this acne treatment.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Severe acne vulgaris presents significant challenges in treatment.
- Resistant acne forms often require aggressive therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy and tolerability of high-dose tetracycline in patients with severe, treatment-resistant acne vulgaris.
Main Methods:
- Thirty-one patients with severe acne (papulopustular, cystic, conglobated) received high daily doses of tetracycline (approx. 2,000 mg) for 3 to 33 months.
Main Results:
- Acne cleared in 14 patients and greatly improved in 13.
- Insignificant improvement was noted in 3 patients; 1 showed no improvement.
- Side effects were reported by 15 patients, but only 3 required treatment cessation.
Conclusions:
- High-dose tetracycline demonstrates significant efficacy in managing severe, treatment-resistant acne vulgaris.
- The treatment is generally well-tolerated, with a low rate of discontinuation due to side effects.