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Generalized exfoliative dermatitis from ethylenediamine.

J W Petrozzi, R N Shore

    Archives of Dermatology
    |April 1, 1976
    PubMed
    Summary
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    Patients allergic to topical antibiotic creams may react to systemic medications containing ethylenediamine hydrochloride. This highlights the importance of checking for cross-reactivity when prescribing systemic drugs.

    Area of Science:

    • Pharmacology
    • Dermatology
    • Allergy and Immunology

    Background:

    • A patient with a known allergy to Mycolog, a topical antibiotic cream containing nystatin, neomycin sulfate, gramicidin, and triamcinolone acetonide, was administered aminophylline.
    • The patient had a history of allergic reaction to the topical preparation.

    Observation:

    • Following administration of aminophylline, the patient developed a generalized exfoliative dermatitis.
    • The observed skin reaction was severe and widespread.

    Findings:

    • The severe dermatological reaction was attributed to ethylenediamine hydrochloride.
    • Ethylenediamine hydrochloride was identified as a common component in both the topical cream (Mycolog) and the systemic medication (aminophylline).

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    Implications:

    • This case underscores the potential for systemic medications to trigger allergic reactions in patients with prior sensitivities to related topical agents.
    • Clinicians must be aware of cross-reactivity risks, particularly with ingredients like ethylenediamine hydrochloride, when prescribing systemic drugs to patients with known topical allergies.