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Interferon pretreatment regulates interferon and interleukin-6 production in L929 cells in a coordinated manner
I Rosztoczy1, J Content, K Megyeri
1Institute of Microbiology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
Journal of Interferon Research
|February 1, 1992
Abstract:
Two sublines of L929 cells with different interferon (IFN)-producing capacities synthesized IFN and interleukin-6 (IL-6) simultaneously in response to Sendai virus infection. IFN pretreatment primed the production of both cytokines. However, the difference in IL-6 production between the "high and low producer" L-cell sublines was about one magnitude of order larger than in the case of their IFN production. The determination of the corresponding mRNA levels also reflected this difference.