Evidence for an internal pool of nucleoside transporters in mammalian reticulocytes
1Department of Biochemistry, McGill University, Montreal, Canada.
Biochimica Et Biophysica Acta
|April 29, 1992
Abstract:
Comparisons of the site specific binding of nitrobenzylthioinosine (NBMPR) to intact and lysed red cells from various mammalian and avian species suggest the presence of a cytoplasmic pool of nucleoside transporters. In some species the cytoplasmic pool is about 50% of the total (mouse). On the average, the cytoplasmic pool is approx. 20% of the surface pool of NBMPR-binding sites. In sheep reticulocytes, both pools disappear in an energy-dependent manner during the maturation of the reticulocyte in vitro.
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