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Bilateral putaminal necrosis caused by methanol poisoning: a case report
1Division of Neurology, Taichung Veterans General Hospital, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|April 1, 1992
Summary
Methanol poisoning can cause bilateral putaminal necrosis. Characteristic CT scan findings, even with negative blood tests, can aid in diagnosing methanol toxicity.
Area of Science:
- Neurology
- Toxicology
Background:
- Methanol poisoning is a serious condition that can lead to severe neurological deficits.
- Early diagnosis is crucial for effective treatment and improved patient outcomes.
Observation:
- A 31-year-old male presented with symptoms of methanol poisoning, including altered consciousness and severe metabolic acidosis.
- Cerebrospinal fluid analysis revealed elevated pressure, red blood cells, and protein levels.
- Initial methanol blood tests were negative, despite clinical suspicion.
Findings:
- Computed tomography (CT) scans demonstrated bilateral putaminal necrosis and cerebral cortical hemorrhage on day 3.
- Follow-up CT on day 22 showed necrosis of subcortical white matter and gyral enhancement.
- These characteristic CT findings were observed despite negative methanol blood test results.
Implications:
- Characteristic CT findings can be instrumental in diagnosing methanol poisoning, especially when blood tests are delayed or negative.
- Neuroimaging plays a vital role in identifying the extent of brain damage in methanol toxicity.
- Prompt recognition of CT patterns can guide timely intervention and management strategies for methanol poisoning.