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Related Experiment Videos

Polysialic acid influences specific pathfinding by avian motoneurons.

J Tang1, L Landmesser, U Rutishauser

  • 1Department of Physiology and Neurobiology, University of Connecticut, Storrs 06269-3042.

Neuron
|June 1, 1992
PubMed
Summary

Polysialic acid (PSA) guides motoneuron axon pathfinding during development. Removing PSA during early axonal segregation causes projection errors, but later removal does not, indicating PSA

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Polysialic acid (PSA) is a post-translational modification of the neural cell adhesion molecule (NCAM).
  • PSA influences cell migration, neurite outgrowth, and synaptic plasticity.
  • Its role in guiding motoneuron projection patterns during development is not fully understood.

Purpose of the Study:

  • To investigate the influence of polysialic acid (PSA) on motoneuron outgrowth and pathway formation.
  • To determine the temporal and spatial pattern of PSA expression during motoneuron development.
  • To assess the effect of PSA removal on motoneuron projection patterns.

Main Methods:

  • Examining the temporal and spatial expression of PSA in developing motoneurons.

Related Experiment Videos

  • Experimentally removing PSA at different developmental stages.
  • Analyzing motoneuron projection patterns following PSA manipulation.

    • Main Results:

    • Motoneurons express PSA as their growth cones segregate into specific pools in the plexus region.
    • PSA levels vary between motoneurons projecting to different targets.
    • Removal of PSA during early axonal segregation in the plexus region led to common projection errors.
    • Later removal of PSA during muscle nerve formation did not cause projection errors.

    Conclusions:

    • PSA plays a crucial role in guiding motoneuron axons during the critical period of axonal segregation in the plexus region.
    • PSA modulates interactions between motoneuron axons and guidance molecules in the plexus region.
    • The timing of PSA expression and removal is critical for accurate motoneuron pathfinding.