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Related Experiment Videos

[Virus and cancer].

P Gariglio1, L M Rangel

  • 1Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.

Salud Publica De Mexico
|May 1, 1992
PubMed
Summary
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Human papillomavirus (HPV) is linked to cervical cancer, a major concern for Mexican women. Cellular and environmental factors, including oncogenes, are crucial for cancer development, aiding early diagnosis and therapy.

Area of Science:

  • Oncology
  • Virology
  • Genetics

Background:

  • Several viruses are associated with human cancers, including Human T-cell Lymphotropic Virus (HTLV-I/II) with leukemias, Epstein-Barr Virus (EBV) with lymphomas, and Hepatitis B Virus (HBV) with hepatocarcinomas.
  • Human Papillomavirus (HPV) is increasingly recognized for its role in genital cancers, particularly cervical carcinoma, which significantly impacts mortality rates among Mexican women.

Purpose of the Study:

  • To review evidence linking viruses to cancer.
  • To emphasize the role of Human Papillomavirus (HPV) in cervical cancer development and its impact on Mexican women's mortality.
  • To explore cellular and environmental factors in tumor induction and development.

Main Methods:

  • Literature review and evidence synthesis.

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  • Focus on Human Papillomavirus (HPV) characteristics and its association with cervical cancer.
  • Discussion of cellular factors like oncogenes and antioncogenes.

    • Main Results:

    • Viruses like HTLV, EBV, HBV, and HPV are strongly associated with specific human cancers.
    • HPV is a significant factor in cervical cancer, with notable mortality in Mexico.
    • Tumor development involves a low percentage of infected individuals, suggesting complex interactions between viral, cellular, and environmental factors.
    • Oncogenes and antioncogenes are implicated in the malignant transformation process.

    Conclusions:

    • Understanding viral oncogenesis, including HPV, is critical for cancer research.
    • Cellular and environmental factors play a key role in viral-induced cancers.
    • Further research into these factors can facilitate the development of early diagnostic and therapeutic strategies for cancer.