Related Experiment Videos
Human papillomavirus associated with bladder cancer
Y F Shibutani1, M P Schoenberg, V L Carpiniello
1Department of Urology, Pennsylvania Hospital, Philadelphia.
Urology
|July 1, 1992
Summary
Human papillomavirus (HPV) genomic material was detected in 20% of bladder tumors from patients without active HPV infection. This finding supports a potential role for HPV in bladder cancer development.
Area of Science:
- Oncology
- Virology
- Urology
Background:
- Recent data suggest a link between active human papillomavirus (HPV) infection and bladder cancer development.
- The role of HPV in bladder cancer, particularly in patients without evidence of current infection, requires further investigation.
Purpose of the Study:
- To investigate the presence of HPV genomic material in bladder tumors from patients without clinical evidence of active HPV infection.
- To determine the prevalence and types of HPV DNA in bladder neoplasia.
Main Methods:
- Cystopanendoscopy and biopsy were performed on 23 patients with intravesical neoplasia and no history of HPV infection.
- Routine histopathology and southern blot analysis were used to detect HPV DNA in biopsy specimens.
Main Results:
- HPV DNA was detected in 4 out of 20 (20%) transitional cell carcinomas.
- HPV genomic material was also found in specimens with moderate dysplasia and cystitis.
- Detected HPV types included 6/11, 16/18, and 31/33.
Conclusions:
- The presence of HPV DNA in bladder tumors, even without active infection, suggests a potential role for HPV in bladder carcinogenesis.
- These findings contribute to understanding viral oncogenesis in the urinary bladder.