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Related Experiment Videos

Urinary leukotriene E4 in bronchial asthma.

C M Smith1, R J Hawksworth, F C Thien

  • 1Dept of Allergy and Allied Respiratory Disorders, Guy's Hospital, London, UK.

The European Respiratory Journal
|June 1, 1992
PubMed
Summary

Urinary leukotriene E4 (LTE4) levels are elevated in aspirin-sensitive asthmatics compared to normal individuals. However, urinary LTE4 does not predict bronchial hyperresponsiveness or airflow obstruction in asthma patients.

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Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology
  • Biochemistry

Background:

  • Leukotriene E4 (LTE4) excretion in urine reflects total body sulphidopeptide leukotriene production.
  • Urinary LTE4 measurement offers a non-invasive method to assess leukotriene production.
  • Asthma is associated with altered inflammatory pathways, potentially involving leukotrienes.

Purpose of the Study:

  • To measure urinary LTE4 levels in normal subjects, non-aspirin-sensitive asthmatics, and aspirin-sensitive asthmatics.
  • To investigate the relationship between urinary LTE4 and bronchial hyperresponsiveness to histamine in non-aspirin-sensitive asthmatics.
  • To determine if urinary LTE4 can predict airflow obstruction in asthma.

Main Methods:

  • Assayed urinary LTE4 in 17 normal, 31 non-aspirin-sensitive asthmatic, and 10 aspirin-sensitive asthmatic subjects.

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  • Assessed bronchial hyperresponsiveness using histamine provocation (PD20 FEV1).
  • Correlated urinary LTE4 with PD20 and baseline FEV1 (% predicted).

    • Main Results:

    • Urinary LTE4 levels were similar in normal and non-aspirin-sensitive asthmatic subjects.
    • Aspirin-sensitive asthmatics exhibited significantly higher urinary LTE4 levels compared to both normal and non-aspirin-sensitive asthmatics.
    • No significant correlation was found between urinary LTE4 and bronchial hyperresponsiveness (PD20) or airflow obstruction (FEV1).

    Conclusions:

    • Urinary LTE4 is elevated in aspirin-sensitive asthmatics, suggesting increased leukotriene production in this subgroup.
    • Despite elevated levels in some asthmatics, urinary LTE4 is not a reliable predictor of bronchial hyperresponsiveness or airflow obstruction.
    • Further research may be needed to elucidate the role of LTE4 in asthma pathophysiology and its clinical utility.