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Updated: Aug 8, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

Two TNF receptors

L A Tartaglia1, D V Goeddel

  • 1Genentech, South San Francisco, CA 94080.

Immunology Today
|May 1, 1992
PubMed

Insights

Tumor necrosis factor (TNF) receptors have been identified, but their distinct roles in TNF signaling remain unclear. A new model proposes how TNF receptor triggering reconciles conflicting data on TNF functions.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Signaling

Background:

  • Significant advancements in identifying and characterizing tumor necrosis factor (TNF) receptors.
  • The specific functions of the two TNF receptor types in mediating TNF's diverse biological effects require further clarification.

Purpose of the Study:

  • To summarize the current understanding of TNF receptor identification and characterization.
  • To propose a model for TNF receptor triggering that integrates existing, seemingly contradictory, experimental findings.

Main Methods:

  • Review and synthesis of existing literature on TNF receptors.
  • Development of a theoretical model for TNF receptor activation.

Main Results:

  • Progress in identifying and characterizing TNF receptors has been substantial.
  • A model is proposed to explain the mechanism of TNF receptor triggering.

Conclusions:

  • The precise roles of individual TNF receptors in TNF-mediated signaling are still under investigation.
  • The proposed model offers a framework for understanding TNF receptor function and reconciling diverse experimental observations.

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