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Mucoid cytoplasmic inclusions in urothelial carcinomas
K Donhuijsen1, U Schmidt, H J Richter
1Institute of Pathology, University of Essen, Germany.
Human Pathology
|August 1, 1992
Summary
Mucoid cytoplasmic inclusions are frequently found in urothelial carcinomas, increasing with tumor grade. These deposits aid in diagnosing metastatic urothelial cancer.
Area of Science:
- Uropathology
- Oncology
- Cellular Biology
Background:
- Mucoid cytoplasmic inclusions in urothelial carcinomas are infrequently documented.
- These inclusions are readily detectable in a significant proportion of urothelial neoplasms.
Purpose of the Study:
- To investigate the prevalence and characteristics of mucoid cytoplasmic inclusions in urothelial carcinomas.
- To assess the potential diagnostic utility of these inclusions in differential diagnosis.
Main Methods:
- Histologic analysis of 100 urothelial carcinoma cases.
- Histochemical staining (Periodic Acid-Schiff).
- Immunohistochemical and ultrastructural analysis.
Main Results:
- 37 out of 100 cases (37%) exhibited Periodic Acid-Schiff-positive cytoplasmic inclusions.
- Inclusion prevalence increased with tumor grade: 14% (grade 1), 49% (grade 2), and 63% (grade 3).
- Inclusions were identified as cytoplasmic mucoid material, with condensed and noncondensed types observed.
Conclusions:
- Mucoid cytoplasmic inclusions are a notable feature in urothelial carcinomas, correlating with higher tumor grade.
- Their presence, particularly in poorly differentiated metastatic carcinomas, can assist in considering urothelial carcinoma as a primary tumor in differential diagnosis.
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