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Does haemodialysis impair macrophage Fc receptor function?
C Halma1, M R Daha, R I Feitsma
1Department of Nephrology, University Hospital Leiden, The Netherlands.
Summary
Patients on chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) show altered immune function. However, Fc receptor function appears normal in HD patients, despite infection risks.
Area of Science:
- Immunology
- Nephrology
- Medical Imaging
Background:
- Patients undergoing chronic dialysis are susceptible to infections.
- Impaired macrophage Fc receptor function is a potential cause of increased infection risk in dialysis patients.
Purpose of the Study:
- To investigate Fc receptor-mediated function in patients undergoing chronic intermittent hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD).
- To compare Fc receptor function in preterminal renal failure patients and healthy controls.
Main Methods:
- Utilized [123I]-labelled aggregates of human IgG ([123I]-AIgG) as a probe for Fc-receptor-mediated function.
- Examined four groups: HD patients, CAPD patients, preterminal renal failure patients, and healthy controls.
Main Results:
- All patient groups exhibited a decreased first elimination half-life of [123I]-AIgG, indicating accelerated probe binding.
- Overall clearance of [123I]-AIgG was similar between HD patients and healthy controls.
- CAPD and preterminal renal failure groups showed decreased clearance compared to HD patients. Hepatic uptake peaked earlier in HD patients.
Conclusions:
- Fc receptor function is not impaired in patients undergoing chronic hemodialysis.
- Altered Fc receptor kinetics in CAPD and preterminal renal failure patients warrant further investigation regarding infection risk.