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LAN-1 human neuroblastoma cells are provided of endothelin-1 receptors linked to [Ca++]i elevation
1Department of Human Communication Sciences, 2nd School of Medicine, Federico II University of Naples, Italy.
Functional Neurology
|May 1, 1992
Abstract:
Endothelin-1 (ET-1) produced a dose-dependent increase of intracellular Ca++ concentrations [Ca++]i characterized by an early peak phase and a delayed plateau in LAN-1 human neuroblastoma cells. The ET-1 receptor showed a rapid desensitization since a second pulse application of ET-1 did not elicit a further [Ca++]i increase. Furthermore thapsigargin, an endoplasmic reticulum Ca(++)-ATPase inhibitor, completely abolished the ET-1 induced intracellular Ca++ elevation.