Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated neutrophil function in chronic neutrophilic leukemia.

T Ohtsuki1, Y Katsura, H Mizukami

  • 1Department of Internal Medicine III, National Defense Medical College, Saitama, Japan.

American Journal of Hematology
|September 1, 1992
PubMed
Summary

This study identifies chronic neutrophilic leukemia in a patient with elevated white blood cells. Neutrophil functions were found to be activated, suggesting a specific disease mechanism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Passive near-field imaging via grating-based spectroscopy.

The Review of scientific instruments·2022
Same author

Correction: Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.

Leukemia·2018
Same author

Predictors of inhalation burn injury using fire site information.

Annals of burns and fire disasters·2018
Same author

Successful management of complete placenta previa after intrauterine fetal death in a second-trimester pregnancy by uterine artery embolization: case report and literature review.

Clinical and experimental obstetrics & gynecology·2018
Same author

Pericardiectomy and pericardium window creation to treat recurrent pericardial tamponade involving a borderline ovarian tumor.

European journal of gynaecological oncology·2018
Same author

Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis.

Leukemia·2017

Area of Science:

  • Hematology
  • Oncology

Background:

  • Leukocytosis, characterized by elevated white blood cell counts, requires careful diagnosis to differentiate various hematological disorders.
  • Chronic myeloid leukemia (CML) and chronic neutrophilic leukemia (CNL) are distinct conditions presenting with increased neutrophils.

Observation:

  • A 65-year-old male presented with marked leukocytosis (37,500 leukocytes/microliter), predominantly mature neutrophil-like cells.
  • Morphological examination revealed toxic granules and Döhle bodies in neutrophils.
  • Neutrophil function tests showed elevated superoxide production, nitroblue tetrazolium reduction, and phagocytosis.

Findings:

  • High neutrophil alkaline phosphatase score and normal bone marrow karyotype supported a diagnosis of chronic neutrophilic leukemia over chronic myeloid leukemia.

Related Experiment Videos

  • The observed neutrophil morphology and functional hyperactivity indicated an activated neutrophil state.

    • Implications:

    • This case highlights key diagnostic markers for differentiating CNL from CML.
    • Understanding neutrophil activation in CNL may offer insights into disease pathogenesis and potential therapeutic targets.