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The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells
B Buisson1, S P Bottari, M de Gasparo
1Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Qué., Canada.
FEBS Letters
|September 7, 1992
Abstract:
We report here that angiotensin II (AII) and the AT2 receptor-selective ligand, CGP 42112, modulate the T-type calcium current in non-differentiated NG108-15 cells, which express only AT2 receptors. Both peptides decrease the T-type calcium current at membrane potentials above -40 mV and shift the current-voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT2 receptor mediates certain neurophysiological actions of this hormone.