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Related Experiment Videos

Baclofen-assisted detoxification from opiates. A pilot study.

J H Krystal1, C J McDougle, T R Kosten

  • 1Psychiatry Service, Yale University School of Medicine, West Haven, CT 06516.

Journal of Substance Abuse Treatment
|January 1, 1992
PubMed
Summary
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Baclofen showed limited success in aiding opiate detoxification, with most patients experiencing insufficient symptom relief. Clonidine proved more effective for completing detoxification in this pilot study.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Research

Background:

  • Opioid dependence is a significant public health issue requiring effective detoxification strategies.
  • Methadone is a common treatment for opioid dependence, necessitating safe and efficient discontinuation protocols.
  • Baclofen is a GABA-B agonist with potential muscle relaxant and anxiolytic properties, explored for detoxification.

Purpose of the Study:

  • To evaluate the efficacy of baclofen as an aid in opiate detoxification.
  • To assess baclofen's ability to manage withdrawal symptoms following abrupt methadone discontinuation.

Main Methods:

  • An open-label pilot study involving five patients dependent on opiates.
  • Patients abruptly discontinued methadone and received oral baclofen up to 80 mg/day.

Related Experiment Videos

  • Symptom reduction and completion of detoxification were monitored.

    • Main Results:

    • All patients reported subjective reduction in discomfort with baclofen.
    • However, 60% (3 out of 5) could not complete detoxification due to inadequate control of vomiting, myalgias, and headache.
    • These three patients successfully completed detoxification using clonidine.

    Conclusions:

    • Baclofen, at the studied doses, appears to have limited utility as a primary agent for opiate detoxification.
    • Further research into adjunctive roles for baclofen in managing opioid withdrawal symptoms is warranted.
    • Clonidine demonstrated effectiveness in facilitating detoxification when baclofen was insufficient.