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Related Experiment Videos

New antifungal agents.

J L Lesher1

  • 1Department of Dermatology, Medical College of Georgia, Augusta.

Dermatologic Clinics
|October 11, 1992
PubMed
Summary
This summary is machine-generated.

Dermatologists can expect new and improved antifungal agents for skin infections. This includes updates on older drugs like ketoconazole and promising new options such as fluconazole and terbinafine.

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Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Antifungal therapy is crucial for treating superficial and deep fungal infections.
  • The landscape of antifungal agents is continually evolving with new drug development.
  • Understanding the efficacy and safety profiles of existing and emerging antifungals is essential for clinical practice.

Purpose of the Study:

  • To provide an update on new information regarding older antifungal agents.
  • To review evolving data on new antifungal agents, including those in clinical trials.
  • To highlight the potential roles of emerging antifungals in dermatological practice.

Main Methods:

  • Review of current literature on antifungal agents.
  • Analysis of clinical trial data for new antifungal drugs.

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  • Discussion of the therapeutic applications and limitations of various antifungal classes.
  • Main Results:

    • Ketoconazole remains a key dermatological antifungal, but requires monitoring for side effects and interactions.
    • Fluconazole's role in cutaneous fungal infections requires further controlled studies.
    • Itraconazole and terbinafine show promise for dermatophyte, candidal, and other challenging fungal infections.
    • Research is ongoing for other antifungal classes like piritetrate, cilofungin, and amorolfine.

    Conclusions:

    • The 1990s are anticipated to offer dermatologists safer and more effective antifungal treatments.
    • Continued research is vital for optimizing the use of antifungal agents in treating cutaneous mycoses.
    • Clinicians must stay informed about the latest advancements in antifungal drug therapy.