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Intranuclear inclusions in the pituitary gland of cynomolgus monkeys
1Safety Evaluation Center, Schering-Plough Research, Lafayette, New Jersey 07848.
Toxicologic Pathology
|January 1, 1992
Abstract:
In a 3-month oral toxicity study of a pharmaceutical agent, intranuclear inclusions were seen in the secretory cells of the pars anterior of the pituitary gland of 22 of 40 cynomolgus monkeys, with similar incidences in control and dosed groups. All monkeys were clinically healthy. Electron microscopic examination revealed that the intranuclear inclusions were cytoplasmic invaginations.