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Retroperitoneal malignant fibrous histiocytoma. Report of two cases
G Zünd1, B Kreienbühl, D Gobet
1Department of Urology, University Hospital of Zürich, Switzerland.
Abstract:
We present 2 cases of malignant fibrous histiocytoma (MFH) of the retroperitoneum. Only 12-14% of all MFH occur in the retroperitoneum. Both patients were operated with the diagnosis of a kidney tumor. The surgical exposure showed a tumor arising from the retroperitoneum, infiltrating or surrounding the kidney. We would like to emphasize that large tumors of the retroperitoneum which resemble kidney tumors can also arise from mesenchymal tissue.
Insights
Malignant fibrous histiocytoma (MFH) in the retroperitoneum is rare, often misdiagnosed as kidney tumors. These mesenchymal tumors can infiltrate or surround the kidney, highlighting diagnostic challenges.
Area of Science:
- Oncology
- Surgical Pathology
- Medical Imaging
Background:
- Malignant fibrous histiocytoma (MFH) is a rare soft tissue sarcoma.
- Retroperitoneal tumors are uncommon, with a significant proportion misdiagnosed.
- Kidney tumors are a common differential diagnosis for retroperitoneal masses.
Observation:
- Two cases of retroperitoneal malignant fibrous histiocytoma (MFH) are presented.
- Both patients initially presented with symptoms suggestive of kidney tumors.
- Surgical exploration revealed tumors originating from the retroperitoneum, involving the kidney.
Findings:
- Retroperitoneal MFH constitutes only 12-14% of all MFH cases.
- Mesenchymal tumors in the retroperitoneum can mimic primary kidney neoplasms.
- Tumor infiltration and encasement of the kidney were observed in both cases.
Implications:
- Emphasizes the importance of considering mesenchymal origins for large retroperitoneal masses.
- Highlights the diagnostic challenges in differentiating retroperitoneal MFH from renal tumors.
- Suggests the need for advanced imaging and potentially biopsy for accurate preoperative diagnosis.