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Signal transduction and gene control: the cAMP pathway
E Borrelli1, J P Montmayeur, N S Foulkes
1Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, U184 INSERM, Faculté de Médecine, Strasbourg, France.
Critical Reviews in Oncogenesis
|January 1, 1992
Summary
Gene transcription is regulated by factors interacting with DNA. Signal pathways activate transcription factors, influencing cAMP-inducible gene expression via CREB and CREM.
Area of Science:
- Molecular Biology
- Gene Regulation
- Signal Transduction
Background:
- Gene transcription relies on trans-acting factors binding to cis-acting elements in promoter regions.
- Intracellular signal transduction pathways, triggered by ligand-receptor interactions, modulate transcription factor activity.
Purpose of the Study:
- To explore the connection between adenylyl cyclase pathway activation and the transcriptional response of cAMP-inducible genes.
- To highlight the role of nuclear transcription factors like CREB and CREM in this process.
Main Methods:
- Review of existing literature on gene regulation and signal transduction pathways.
- Analysis of the interplay between the adenylyl cyclase pathway and transcription factors.
Main Results:
- The adenylyl cyclase pathway activation leads to transcriptional changes in cAMP-inducible genes.
- Transcription factors, including CREB (cAMP response element-binding protein) and CREM (cAMP response element modulator), are key mediators.
Conclusions:
- The adenylyl cyclase pathway and transcription factors like CREB and CREM are integral to regulating cAMP-inducible gene expression.
- Understanding these molecular mechanisms is crucial for deciphering cellular responses to external stimuli.