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CD28 co-stimulation of T-cell-mediated cytotoxicity
M Azuma1, J H Phillips, L L Lanier
1Department of Immunology, DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA 94304.
International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement
|January 1, 1992
Abstract:
Co-stimulation via the CD28 pathway permits small, resting human peripheral-blood T lymphocytes to mediate anti-CD3 monoclonal antibody (MAb) "re-directed" cytotoxicity. The effector cells are contained with the "memory" population of T lymphocytes, identified by expression of the CD45RO differentiation antigen. In this article, we review the requirements for initiating a cytolytic response and speculate on the physiological consequences of this process.