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Preparation and stability of a radioiodinated pentamidine isethionate analog
P J Blower1, C M Smith, R J Smith
1Nuclear Medicine Department, Kent and Canterbury Hospital, England.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|October 1, 1992
Abstract:
Iodopentamidine isethionate was heated for 70 min with [I-123]- or [I-125]-sodium iodide and ammonium sulphate in the absence of solvent at 140 degrees C. The product, [I-123]- or [I-125]-iodopentamidine isethionate, was purified by ion exchange chromatography. It was stable at room temperature in aqueous solution over several days, in human blood in vitro for at least 24 h (showing no binding to either cells or proteins), in urine over at least 15 h, and during nebulization in both ultrasonic and jet nebulizers.