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Related Experiment Videos

Oxidized orlon as a blood interface.

J N Ross, J T Wright, S Eskin

    Journal of Biomedical Materials Research
    |July 1, 1976
    PubMed
    Summary
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    Oxidized polyacrylonitrile (Orlon) fabric shows promise as a biomaterial. This carbonized fabric developed a smooth fibrin layer in canine atrial implants and a calf bypass pump, indicating good biocompatibility.

    Area of Science:

    • Biomaterials Science
    • Cardiovascular Surgery
    • Textile Engineering

    Background:

    • Polyacrylonitrile fabric (Orlon) can be oxidized via heat treatment, resulting in a black, carbonized material.
    • This oxidation process causes fiber shrinkage, enabling shape molding for components like diaphragms.
    • Oxidation decreases tensile strength and stiffness but is explored for biomedical applications.

    Purpose of the Study:

    • To evaluate the cytotoxic effects of oxidized Orlon in tissue culture.
    • To assess the biocompatibility of oxidized Orlon as atrial patches in canine models.
    • To investigate the performance of an oxidized Orlon left ventricular bypass pump in a calf model.

    Main Methods:

    • Oxidized Orlon was tested for cytotoxicity in tissue culture.

    Related Experiment Videos

  • Atrial patches of oxidized Orlon and Dacron velour were implanted in dogs.
  • A left ventricular bypass pump made of oxidized Orlon was implanted in a calf.

    • Main Results:

    • No cytotoxic effects were observed for oxidized Orlon in tissue culture.
    • In canine atrial implants, oxidized Orlon consistently formed a thinner, smoother fibrin layer than Dacron velour.
    • The calf bypass pump demonstrated a thin, smooth, and adherent fibrin layer after implantation.

    Conclusions:

    • Oxidized Orlon exhibits favorable biocompatibility for cardiovascular applications.
    • The material's ability to form a smooth fibrin layer suggests reduced thrombogenicity.
    • Oxidized Orlon is a viable candidate for fabricating cardiovascular devices such as bypass pumps and atrial patches.