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Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
D H Ohlendorf1, S I Foundling, J J Wendoloski
1Du Pont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0228.
Proteins
|November 1, 1992
Abstract:
The structure of the retroviral proteinase from avian myeloblastosis associated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human immunodeficiency type 1 virus (HIV). Through comparison with the structure of a proteinase-inhibitor complex from HIV, a model of a complex between MAV proteinase and a peptide substrate has been generated. Examination of this model suggests structural basis for the diverse specifications of viral proteinases.