The fall and rise of neuronal alpha-bungarotoxin binding proteins

Although neuronal [125I]-alpha-bungarotoxin binding proteins are similar in many respects to muscle nicotinic acetylcholine receptors, their functional significance has eluded researchers for the past fifteen years. Over this period, their status became increasingly doubtful, as almost all attempts failed to demonstrate that alpha-bungarotoxin could block neuronal nicotinic responses. Recently, these enigmatic proteins have been cloned and expressed in oocytes, and have been examined afresh in their native state. As Paul Clarke explains, it is time to recognize neuronal alpha-bungarotoxin binding proteins as distinct members of the nicotinic acetylcholine receptor gene family, even if perhaps they do not function quite like other members.