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Updated: Sep 5, 2026
An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Atlantoaxial dislocation in a patient with Neurofibromatosis type 1: Case report and review
Abolfazl Rahimizadeh1, Housain Soufiani1, Khodakaram Rastegar2
1Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Tehran, Iran.
Background:
Neurofibromatosis type 1 (NF1) or von Recklinghausen's disease is a complex multi-system genetic disorder characterized by neurocutaneous manifestations, nervous system affection, and various skeletal dysplasia. Rarely, this disorder might be associated with atlantoaxial dislocation (AAD).
Case Description:
A 65-year-old male with a prior diagnosis of (NF1) was referred due to progressive spastic quadriparesis. Dynamic cervical spine radiographs and magnetic resonance showed reducible AAD with cervicomedullary cord compression/myelopathy. Triple construct C1-C2 screw-rod-hook fixation results in steady postoperative neurological recovery.
Conclusion:
Here, we reviewed the clinical presentation, diagnostic challenges, and surgical fusion for C1-C2 instability in a 65-year-old male with type 1 (NF1) and cervicomedullary cord compression.
